Publisher:
JOURNAL OF DIETARY SUPPLEMENTS
Publication Type:
Journal
Publication Title:
Seeds Of Buchholzia Coriacea In Diet Mitigate Ischemic Reperfusion–Induced Gastric Ulceration In Experimental Rats
Publication Authors:
Adeola Temitope Salami, Olugbenga Adeola Odukanmi, Omosola Fisayo Faniyan, Tosan Peter Omayone &
Year Published:
2012
Abstract:
Buchholzia coriacea (B. coriacea) seeds, in folk medicine, have been
documented to prevent gastric ulceration though the mechanism is
not fully elucidated. To clarify this, the gastro-healing activities were
investigated using graded incorporation of B. coriacea seeds in the
diet. Male Wistar rats (150–200 g) were divided into 7 groups (n = 15):
unulcerated untreated control, ulcerated untreated control, unulcerated
B. coriacea low (10%), ulcerated B. coriacea low (10%), nulcerated
B. coriacea high (25%), ulcerated B. coriacea high (25%), and ulcerated
omeprazole-treated groups. Rats were fed with B. coriacea diets for
7 weeks; thereafter, ulcer was induced by ischemic reperfusionmethod.
Daily body weight, gastric acid secretion, hematological parameters,
stomach ulcer score, and biochemical and histological analyses were
evaluated on days 0, 3, and 7 post–ulcer induction. Results were
subjected to one-way analysis of variance (ANOVA) and presented as
mean ± standard error of the mean (SEM); p .05 was considered significant.
Significant decreases were observed in mean body weight of
B. coriacea–fed compared with control and omeprazole-treated groups
from week 7. Ulcerated B. coriacea–fed showed significant decrease in
gastric acid secretion by days 3 and 7 compared with ulcerated control
groups. Malondialdehyde content was significantly decreased in ulcerated
B. coriacea–fed compared with control and omeprazole–treated
groups. Significant increases in hematological variables (notably
platelet count), superoxide dismutase, catalase, and nitric oxide levels
of B. coriacea–fed compared with control and omeprazole-treated
groups by days 0 and 3 were observed. Histological evaluations further
confirmed these observations. B. coriacea diet enhanced gastric healing
activities on ischemic reperfused gastric ulcer. Increased platelet count
and nitric oxide levels may play significant roles in